Liz Cheney as secretary of defense? You laugh, you snort, you spew that pumpkin-spice latte all over your keyboard, but it could happen if Kamala Harris defeats Donald Trump.

On Wednesday at North Carolina’s Duke University, before a youthful gathering of low-information voters, Cheney once again put her Trump derangement ahead of country when she endorsed Kamala Harris for president — just like Adam Kinzinger at the DNC, David French on the pages of The New York Times, and dozens of other Republicans in Name Only.

“As a conservative,” she told the credulous crowd, “as someone who believes in and cares about the Constitution, I have thought deeply about this — and because of the danger that Donald Trump poses, not only am I not voting for Donald Trump, but I will be voting for Kamala Harris.”

But lest you think Cheney asked her audience for their write-in votes, she said there was simply too much at stake. “I don’t believe that we have the luxury of writing in candidates’ names, particularly in swing states,” she fretted.

Cheney is thus living up to her vow to sabotage the Republican Party and the will of its voters by any means necessary. That is why she was there at Duke, in the swing state of North Carolina, and not somewhere closer to home, like Laramie, where she could’ve delivered the exact same message to a dozen or so impressionable University of Wyoming students.

Clearly, Liz can’t take a hint. The good people of Wyoming sent an unequivocal message to her during the 2022 midterms when they resoundingly kicked her to the curb in a crushing 37-point primary loss to Harriet Hageman.

Has there ever been a more thorough and breathtaking collapse of political credibility than the one that Cheney has inflicted upon herself? Remember: This is the former chair of the Republican conference, a rising star of the party, and the third-ranking Republican in the House. And this is what she rightly said about the dim-witted Bay Area progressive’s presidential aspirations four years ago: “Kamala Harris is a radical liberal who would raise taxes, take away guns & health insurance, and explode the size and power of the federal gov’t. She wants to recreate America in the image of what’s happening on the streets of Portland & Seattle. We won’t give her the chance.”

Alas, now Cheney is giving her a chance. She’s voting for the “radical liberal.” Which brings us back to the possibility of a cabinet post in a Harris administration.

Last week, during her pre-recorded softball interview with CNN, Harris immediately answered what seemed to be a scripted question from Dana Bash: “Will you appoint a Republican to your cabinet?”

“Yes, I would. Yes, I would,” replied Harris.

When Bash asked if she had anyone in particular in mind, Harris’s answer suggested that she’d already given plenty of thought to the question: “No. No one in particular mind. I got a — we got 68 days to go in this election, so I’m not putting the cart before the horse, but I would. I think — I think it’s really important. I — I have spent my career inviting diversity of opinion. I think it’s important to have people at the table and when some of the most important decisions are being made that have different views, different experiences, and I think — uh — it would be to the benefit of the American public to have a member of my cabinet who was a Republican.”

Admittedly, it’d be a stretch for the hard-left Harris to appoint the war-hawkish Cheney, but the Democrats have increasingly become the Party of Endless War. At the same time, the Republicans, under Donald Trump, have gotten back to their mid-20th-century roots as an America First party — a party disinclined to commit our warriors to what Trump has called “stupid wars.”

And that’s the rub. That’s the real reason for Liz Cheney’s Trump derangement and her Soviet-style scorched-earth approach toward the political party she once called home. Trump insulted her dad.

In a weird and pathetic video two years ago, just prior to the clobbering of his daughter in Wyoming’s Republican primary, Dick Cheney said this: “In our nation’s 246-year history, there has never been an individual who is a greater threat to our republic than Donald Trump.”

This from the guy who, as The Babylon Bee memorably put it, “started two wars and shot a dude in the face.”

Once rock-ribbed Republicans, where Trump is concerned, the Cheney family have come unhinged — so much so that they’re willing to endorse a San Francisco leftist for president.

It’s sad, but it’s true.